Professor, Department of Medicine
Office: 905-521-2100 Ext 40788
Dr. Patricia Liaw is a Professor at McMaster University in the Department of Medicine (Division of Hematology and Thromboembolism) and the Jack Hirsh Professorship in Thrombosis. She is also the Chair of the Canadian Critical Care Translational Biology Group (CCCTBG). Her overall research interest is to study the mechanistic links between blood clotting, inflammation, and the host immune system. Her approach is to integrate basic studies with translational/clinical research projects to better understand why dysregulation of these pathways contributes to morbidity and mortality in a variety of vascular disease states.
Dr. Liaw’s current research focuses on three key areas: (1) extracellular DNA as a novel link between coagulation, inflammation, and innate immunity in sepsis, (2) biochemical and genetic determinants of thrombosis, and (3) mechanisms of thrombosis in cancer patients.
Her integrative research approach includes studies at the levels of cell biology, biochemistry, molecular biology, and clinical research studies. The techniques utilized in her research include flow cytometry, cytokine and apoptosis assays, confocal microscopy, tissue culture, protein expression and purification, studies of human blood, and mouse models of thrombosis and sepsis.
Lab Alumni and where they are now:
Vinai Bhagirath, MD, MSc: Assistant Professor, Division of Hematology, McMaster University
Zakhar Lysov, PhD: Shire Pharmaceuticals
Travis Gould, PhD: Pfizer Pharmaceuticals
Laura Pepler, PhD: Roche Pharmaceuticals
Laura Swystun, PhD - Senior Clinical Scientist, Queen's University, Kingston, Ontario.
Cynthia Wu, MD - Associate Professor, Department of Hematology, University of Alberta, Edmonton.
Joel Woodley-Cook, MSc, MD - University of Toronto, Department of Medical Imaging
D. Aaron Stephenson, MSc, LL.B - Associate Norton Rose Canada LLP
Lisa Toltl, PhD – AstraZeneca Canada
Peter Grin, MSc – PhD candidate at University of British Columbia
Andrew Kwong - PhD candidate at Harvard University
Maher Jibrini - Pharmacy, University of Waterloo